Glucosamine and chondroitin are two of the most basic and important molecules necessary for the support of joints and the synthesis of cartilage within those joints which supports mobility and reduces discomfort.‡
Manganese is added to the formula for its properties relative to supporting healthy inflammation levels in the joints and connective tissues, reducing discomfort.‡
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
Take two capsules twice daily.
Science
Fox BA, Stephens MM. Glucosamine hydrochloride for the treatment of osteoarthritis symptoms. Clin Interv Aging. 2007;2(4):599-604. doi: 10.2147/cia.s1632. PMID: 18225460; PMCID: PMC2686334.
Bissett DL. Glucosamine: an ingredient with skin and other benefits. J Cosmet Dermatol. 2006 Dec;5(4):309-15. doi: 10.1111/j.1473-2165.2006.00277.x. PMID: 17716251.
Navarro SL, White E, Kantor ED, Zhang Y, Rho J, Song X, Milne GL, Lampe PD, Lampe JW. Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans. PLoS One. 2015 Feb 26;10(2):e0117534. doi: 10.1371/journal.pone.0117534. PMID: 25719429; PMCID: PMC4342228.
Kantor ED, Lampe JW, Navarro SL, Song X, Milne GL, White E. Associations between glucosamine and chondroitin supplement use and biomarkers of systemic inflammation. J Altern Complement Med. 2014 Jun;20(6):479-85. doi: 10.1089/acm.2013.0323. Epub 2014 Apr 16. PMID: 24738579; PMCID: PMC4048982.
Kantor ED, O’Connell K, Du M, Cao C, Zhang X, Lee DH, Cao Y, Giovannucci EL. Glucosamine and Chondroitin Use in Relation to C-Reactive Protein Concentration: Results by Supplement Form, Formulation, and Dose. J Altern Complement Med. 2021 Feb;27(2):150-159. doi: 10.1089/acm.2020.0283. Epub 2020 Dec 7. PMID: 33290138; PMCID: PMC7891193.
Yamagishi Y, Someya A, Imai K, Nagao J, Nagaoka I. Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells. Mol Med Rep. 2017 Aug;16(2):1353-1359. doi: 10.3892/mmr.2017.6691. Epub 2017 Jun 6. PMID: 28586015.
Someya A, Ikegami T, Sakamoto K, Nagaoka I. Glucosamine Downregulates the IL-1β-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and -Independent Mechanisms. PLoS One. 2016 Oct 24;11(10):e0165158. doi: 10.1371/journal.pone.0165158. PMID: 27776166; PMCID: PMC5077170.
Jerosch J. Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. Int J Rheumatol. 2011;2011:969012. doi: 10.1155/2011/969012. Epub 2011 Aug 2. PMID: 21826146; PMCID: PMC3150191.
Henrotin Y, Mathy M, Sanchez C, Lambert C. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. doi: 10.1177/1759720X10383076. PMID: 22870459; PMCID: PMC3383492.
Das A Jr, Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000 Sep;8(5):343-50. doi: 10.1053/joca.1999.0308. PMID: 10966840.
Features :
Hygienic Product : Not Specified
Allergy : Not Specified
G/C 1000® - 7232
Description
Glucosamine and chondroitin are two of the most basic and important molecules necessary for the support of joints and the synthesis of cartilage within those joints which supports mobility and reduces discomfort.‡
Manganese is added to the formula for its properties relative to supporting healthy inflammation levels in the joints and connective tissues, reducing discomfort.‡
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
Take two capsules twice daily.
Science
Fox BA, Stephens MM. Glucosamine hydrochloride for the treatment of osteoarthritis symptoms. Clin Interv Aging. 2007;2(4):599-604. doi: 10.2147/cia.s1632. PMID: 18225460; PMCID: PMC2686334.
Bissett DL. Glucosamine: an ingredient with skin and other benefits. J Cosmet Dermatol. 2006 Dec;5(4):309-15. doi: 10.1111/j.1473-2165.2006.00277.x. PMID: 17716251.
Navarro SL, White E, Kantor ED, Zhang Y, Rho J, Song X, Milne GL, Lampe PD, Lampe JW. Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans. PLoS One. 2015 Feb 26;10(2):e0117534. doi: 10.1371/journal.pone.0117534. PMID: 25719429; PMCID: PMC4342228.
Kantor ED, Lampe JW, Navarro SL, Song X, Milne GL, White E. Associations between glucosamine and chondroitin supplement use and biomarkers of systemic inflammation. J Altern Complement Med. 2014 Jun;20(6):479-85. doi: 10.1089/acm.2013.0323. Epub 2014 Apr 16. PMID: 24738579; PMCID: PMC4048982.
Kantor ED, O’Connell K, Du M, Cao C, Zhang X, Lee DH, Cao Y, Giovannucci EL. Glucosamine and Chondroitin Use in Relation to C-Reactive Protein Concentration: Results by Supplement Form, Formulation, and Dose. J Altern Complement Med. 2021 Feb;27(2):150-159. doi: 10.1089/acm.2020.0283. Epub 2020 Dec 7. PMID: 33290138; PMCID: PMC7891193.
Yamagishi Y, Someya A, Imai K, Nagao J, Nagaoka I. Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells. Mol Med Rep. 2017 Aug;16(2):1353-1359. doi: 10.3892/mmr.2017.6691. Epub 2017 Jun 6. PMID: 28586015.
Someya A, Ikegami T, Sakamoto K, Nagaoka I. Glucosamine Downregulates the IL-1β-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and -Independent Mechanisms. PLoS One. 2016 Oct 24;11(10):e0165158. doi: 10.1371/journal.pone.0165158. PMID: 27776166; PMCID: PMC5077170.
Jerosch J. Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. Int J Rheumatol. 2011;2011:969012. doi: 10.1155/2011/969012. Epub 2011 Aug 2. PMID: 21826146; PMCID: PMC3150191.
Henrotin Y, Mathy M, Sanchez C, Lambert C. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. doi: 10.1177/1759720X10383076. PMID: 22870459; PMCID: PMC3383492.
Das A Jr, Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000 Sep;8(5):343-50. doi: 10.1053/joca.1999.0308. PMID: 10966840.
