Ortho-Gesic® is a unique combination of two state-of- the-art dietary ingredients – NEM® natural eggshell membrane, and UC-II® collagen. These ingredients are combined in clinically studied amounts designed to support healthy joints.‡
NEM® is an eggshell membrane ingredient which is clinically proven to improve joint health and flexibility faster than any other joint health ingredient.‡
Composed of naturally occurring glycosaminoglycans including chondroitin and hyaluronic acid, NEM® also contains collagen and other beneficial proteins. Clinical studies show that NEM® reduces pain and stiffness and improves flexibility in just 7 to 10 days.‡
One third of patients had a greater than 30% reduction in pain in 7 to 10 days.‡
One fourth of patients had a greater than 50% reduction in stiffness in 10 days.‡
NEM®’s natural anti-inflammatory properties reduce proinflammatory cytokines which may slow joint degradation.‡
Derived from chicken sternum cartilage, UC-II® consists of undenatured type II collagen that supports joint comfort, flexibility and mobility. Supported by two human clinical studies and backed by numerous patents, UC-II® is the only source of undenatured type II collagen available as a powdered, shelf stable dietary ingredient. Just 40 mg of UC-II® has been shown to increase joint comfort, flexibility and mobility.‡
UC-II® is manufactured in a GMP-certified facility from chicken sternum cartilage using a patented, low-temperature manufacturing process that ensures a particular level of undenatured type II collagen. Other forms of type II collagen sold as dietary supplements are denatured, or hydrolyzed.‡
A new UC-II® randomized, double-blind, placebo controlled study was conducted on healthy subjects. UC-II® provided significant results compared to placebo in increasing joint function. UC-II® consists of undenatured type II collagen, a FDA-notified and published new dietary ingredient (NDI). UC-II® is manufactured in a GMP-certified facility and has been determined GRAS for use in foods and beverages.
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
One capsule daily.
Count
SKU 1014 – 30 Capsules
SKU 10146 – 60 Capsules
Science
Gencoglu H, Orhan C, Sahin E, Sahin K. Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals. Animals (Basel). 2020 Apr 17;10(4):697. doi: 10.3390/ani10040697. PMID: 32316397; PMCID: PMC7222752.
Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J. 2016 Jan 29;15:14. doi: 10.1186/s12937-016-0130-8. PMID: 26822714; PMCID: PMC4731911.
Lugo JP, Saiyed ZM, Lau FC, Molina JP, Pakdaman MN, Shamie AN, Udani JK. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr. 2013 Oct 24;10(1):48. doi: 10.1186/1550-2783-10-48. PMID: 24153020; PMCID: PMC4015808.
Ruff KJ, DeVore DP, Leu MD, Robinson MA. Eggshell membrane: a possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies. Clin Interv Aging. 2009;4:235-40. doi: 10.2147/cia.s5797. Epub 2009 Jun 9. PMID: 19554094; PMCID: PMC2697588.
Shi, Y., Zhou, K., Li, D., Guyonnet, V., Hincke, M.T., & Mine, Y. (2021) Avian eggshell membrane as a novel biomaterial: A review. Foods, 10, 2178.
Benson, K.F., Ruff, K.J. & Jensen, G.S. (2012) Effects of natural eggshell membrane (NEM) on cytokine production in cultures of peripheral blood mononuclear cells: increased suppression of tumor necrosis factor-α levels after in vitro digestion. Journal of Medicinal Food, 15(4), 360-368.
Features :
Hygienic Product : Not Specified
Allergy : Not Specified
Ortho-Gesic® - OG-01
Description
Ortho-Gesic® is a unique combination of two state-of- the-art dietary ingredients – NEM® natural eggshell membrane, and UC-II® collagen. These ingredients are combined in clinically studied amounts designed to support healthy joints.‡
NEM® is an eggshell membrane ingredient which is clinically proven to improve joint health and flexibility faster than any other joint health ingredient.‡
Composed of naturally occurring glycosaminoglycans including chondroitin and hyaluronic acid, NEM® also contains collagen and other beneficial proteins. Clinical studies show that NEM® reduces pain and stiffness and improves flexibility in just 7 to 10 days.‡
One third of patients had a greater than 30% reduction in pain in 7 to 10 days.‡
One fourth of patients had a greater than 50% reduction in stiffness in 10 days.‡
NEM®’s natural anti-inflammatory properties reduce proinflammatory cytokines which may slow joint degradation.‡
Derived from chicken sternum cartilage, UC-II® consists of undenatured type II collagen that supports joint comfort, flexibility and mobility. Supported by two human clinical studies and backed by numerous patents, UC-II® is the only source of undenatured type II collagen available as a powdered, shelf stable dietary ingredient. Just 40 mg of UC-II® has been shown to increase joint comfort, flexibility and mobility.‡
UC-II® is manufactured in a GMP-certified facility from chicken sternum cartilage using a patented, low-temperature manufacturing process that ensures a particular level of undenatured type II collagen. Other forms of type II collagen sold as dietary supplements are denatured, or hydrolyzed.‡
A new UC-II® randomized, double-blind, placebo controlled study was conducted on healthy subjects. UC-II® provided significant results compared to placebo in increasing joint function. UC-II® consists of undenatured type II collagen, a FDA-notified and published new dietary ingredient (NDI). UC-II® is manufactured in a GMP-certified facility and has been determined GRAS for use in foods and beverages.
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
One capsule daily.
Count
SKU 1014 – 30 Capsules
SKU 10146 – 60 Capsules
Science
Gencoglu H, Orhan C, Sahin E, Sahin K. Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals. Animals (Basel). 2020 Apr 17;10(4):697. doi: 10.3390/ani10040697. PMID: 32316397; PMCID: PMC7222752.
Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J. 2016 Jan 29;15:14. doi: 10.1186/s12937-016-0130-8. PMID: 26822714; PMCID: PMC4731911.
Lugo JP, Saiyed ZM, Lau FC, Molina JP, Pakdaman MN, Shamie AN, Udani JK. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr. 2013 Oct 24;10(1):48. doi: 10.1186/1550-2783-10-48. PMID: 24153020; PMCID: PMC4015808.
Ruff KJ, DeVore DP, Leu MD, Robinson MA. Eggshell membrane: a possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies. Clin Interv Aging. 2009;4:235-40. doi: 10.2147/cia.s5797. Epub 2009 Jun 9. PMID: 19554094; PMCID: PMC2697588.
Shi, Y., Zhou, K., Li, D., Guyonnet, V., Hincke, M.T., & Mine, Y. (2021) Avian eggshell membrane as a novel biomaterial: A review. Foods, 10, 2178.
Benson, K.F., Ruff, K.J. & Jensen, G.S. (2012) Effects of natural eggshell membrane (NEM) on cytokine production in cultures of peripheral blood mononuclear cells: increased suppression of tumor necrosis factor-α levels after in vitro digestion. Journal of Medicinal Food, 15(4), 360-368.
