5-methyltetrahydrofolate, or 5MTHF or methyl folate, is the most biologically active form of the B-vitamin folate. For years the medical profession, and even the FDA, have used the terms folate and folic acid interchangeably; however, folic acid and folate are not the came. Folic acid is the synthetic form which has been used in medicines and dietary supplements for years.‡
While folic acid has high bioavailability, there is a fairly complex process in the body to convert folic acid to the metabolically active form – 5-methyltetrahydrofolate – which requires a number of enzymes, adequate liver and intestinal function, and the availability of vitamins B2, B3, B6, vitamin C and serine. The lack of these compounds, or compromised liver or intestinal function, may impair the body’s ability to properly convert and absorb folic acid.‡
Supplementation with Methyl Folate may enhance the body’s ability to absorb folate in many people.‡
Taking folate as Methyl Folate can help provide nutritional support for your brain and body. This versatile supplement is also fundamental to the growth and renewal of our cells, helps regulate potentially harmful homocysteine, promotes healthy pregnancy, and is essential for mood, cognition, behavior, and overall brain and body health.
Methyl from MF is needed from the moment of fertilization of the human egg, through the development of the brain, heart and other organs, to birth, and across the lifespan. All our cells need methyl groups to make their DNA, repair ongoing DNA damage, and regulate their utilization of DNA.
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
One vegetable capsule daily with a meal.
Count
60 vegetable capsules
Science
Hardin A, Baldwin-Sayre C. L-Methylfolate as a Monotherapy for Treatment-Resistant Depression: A Case Study. Integr Med (Encinitas). 2020 Aug;19(4):14-18. PMID: 33132780; PMCID: PMC7572139.
Martone G. Enhancement of recovery from mental illness with l-methylfolate supplementation. Perspect Psychiatr Care. 2018 Apr;54(2):331-334. doi: 10.1111/ppc.12227. Epub 2017 Jun 8. PMID: 28597528.
Kaushansky K, et al., eds. Folate, cobalamin, and megaloblastic anemias. In: Williams Hematology. 9th ed. New York, N.Y.: McGraw-Hill Education; 2016.
Paniz C, Bertinato JF, Lucena MR, De Carli E, Amorim PMDS, Gomes GW, Palchetti CZ, Figueiredo MS, Pfeiffer CM, Fazili Z, Green R, Guerra-Shinohara EM. A Daily Dose of 5 mg Folic Acid for 90 Days Is Associated with Increased Serum Unmetabolized Folic Acid and Reduced Natural Killer Cell Cytotoxicity in Healthy Brazilian Adults. J Nutr. 2017 Sep;147(9):1677-1685. doi: 10.3945/jn.117.247445. Epub 2017 Jul 19. PMID: 28724658; PMCID: PMC5712455.
Plumptre L, Masih SP, Ly A, Aufreiter S, Sohn KJ, Croxford R, Lausman AY, Berger H, O’Connor DL, Kim YI. High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood. Am J Clin Nutr. 2015 Oct;102(4):848-57. doi: 10.3945/ajcn.115.110783. Epub 2015 Aug 12. PMID: 26269367.
Paniz C, Lucena MR, Bertinato JF, Lourenço FR, Barros BCA, Gomes GW, Figueiredo MS, Cançado RD, Blaia-D Avila VLN, Pfeiffer CM, Fazili Z, Green R, Carvalho VM, Guerra-Shinohara EM. Daily supplementation with 5 mg of folic acid in Brazilian patients with hereditary spherocytosis. J Investig Med. 2019 Dec;67(8):1110-1117. doi: 10.1136/jim-2019-001025. Epub 2019 May 9. PMID: 31076457; PMCID: PMC7065022.
Henderson AM, Aleliunas RE, Loh SP, Khor GL, Harvey-Leeson S, Glier MB, Kitts DD, Green TJ, Devlin AM. l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women. J Nutr. 2018 Jun 1;148(6):885-890. doi: 10.1093/jn/nxy057. PMID: 29878267.
Venn BJ, Green TJ, Moser R, Mann JI. Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study. Am J Clin Nutr. 2003 Mar;77(3):658-62. doi: 10.1093/ajcn/77.3.658. PMID: 12600857.
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Description
5-methyltetrahydrofolate, or 5MTHF or methyl folate, is the most biologically active form of the B-vitamin folate. For years the medical profession, and even the FDA, have used the terms folate and folic acid interchangeably; however, folic acid and folate are not the came. Folic acid is the synthetic form which has been used in medicines and dietary supplements for years.‡
While folic acid has high bioavailability, there is a fairly complex process in the body to convert folic acid to the metabolically active form – 5-methyltetrahydrofolate – which requires a number of enzymes, adequate liver and intestinal function, and the availability of vitamins B2, B3, B6, vitamin C and serine. The lack of these compounds, or compromised liver or intestinal function, may impair the body’s ability to properly convert and absorb folic acid.‡
Supplementation with Methyl Folate may enhance the body’s ability to absorb folate in many people.‡
Taking folate as Methyl Folate can help provide nutritional support for your brain and body. This versatile supplement is also fundamental to the growth and renewal of our cells, helps regulate potentially harmful homocysteine, promotes healthy pregnancy, and is essential for mood, cognition, behavior, and overall brain and body health.
Methyl from MF is needed from the moment of fertilization of the human egg, through the development of the brain, heart and other organs, to birth, and across the lifespan. All our cells need methyl groups to make their DNA, repair ongoing DNA damage, and regulate their utilization of DNA.
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
One vegetable capsule daily with a meal.
Count
60 vegetable capsules
Science
Hardin A, Baldwin-Sayre C. L-Methylfolate as a Monotherapy for Treatment-Resistant Depression: A Case Study. Integr Med (Encinitas). 2020 Aug;19(4):14-18. PMID: 33132780; PMCID: PMC7572139.
Martone G. Enhancement of recovery from mental illness with l-methylfolate supplementation. Perspect Psychiatr Care. 2018 Apr;54(2):331-334. doi: 10.1111/ppc.12227. Epub 2017 Jun 8. PMID: 28597528.
Kaushansky K, et al., eds. Folate, cobalamin, and megaloblastic anemias. In: Williams Hematology. 9th ed. New York, N.Y.: McGraw-Hill Education; 2016.
Paniz C, Bertinato JF, Lucena MR, De Carli E, Amorim PMDS, Gomes GW, Palchetti CZ, Figueiredo MS, Pfeiffer CM, Fazili Z, Green R, Guerra-Shinohara EM. A Daily Dose of 5 mg Folic Acid for 90 Days Is Associated with Increased Serum Unmetabolized Folic Acid and Reduced Natural Killer Cell Cytotoxicity in Healthy Brazilian Adults. J Nutr. 2017 Sep;147(9):1677-1685. doi: 10.3945/jn.117.247445. Epub 2017 Jul 19. PMID: 28724658; PMCID: PMC5712455.
Plumptre L, Masih SP, Ly A, Aufreiter S, Sohn KJ, Croxford R, Lausman AY, Berger H, O’Connor DL, Kim YI. High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood. Am J Clin Nutr. 2015 Oct;102(4):848-57. doi: 10.3945/ajcn.115.110783. Epub 2015 Aug 12. PMID: 26269367.
Paniz C, Lucena MR, Bertinato JF, Lourenço FR, Barros BCA, Gomes GW, Figueiredo MS, Cançado RD, Blaia-D Avila VLN, Pfeiffer CM, Fazili Z, Green R, Carvalho VM, Guerra-Shinohara EM. Daily supplementation with 5 mg of folic acid in Brazilian patients with hereditary spherocytosis. J Investig Med. 2019 Dec;67(8):1110-1117. doi: 10.1136/jim-2019-001025. Epub 2019 May 9. PMID: 31076457; PMCID: PMC7065022.
Henderson AM, Aleliunas RE, Loh SP, Khor GL, Harvey-Leeson S, Glier MB, Kitts DD, Green TJ, Devlin AM. l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women. J Nutr. 2018 Jun 1;148(6):885-890. doi: 10.1093/jn/nxy057. PMID: 29878267.
Venn BJ, Green TJ, Moser R, Mann JI. Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study. Am J Clin Nutr. 2003 Mar;77(3):658-62. doi: 10.1093/ajcn/77.3.658. PMID: 12600857.
