Twilight Time™ is a unique formulation that helps to promote serotonin production in order to support a restful sleep.‡
L-Tryptophan is an essential amino acid that the body requires to synthesize proteins and specialized molecules such as the neurotransmitter serotonin. Serotonin appears to play significant roles in sleep, emotional moods, pain control, inflammation, intestinal peristalsis, and other body functions.‡
The terpenes, part of the pleasant smelling volatile oil from lemon balm, are thought to produce this herb’s relaxing and gas-relieving (carminative) effects.‡
L-Theanine is an amino acid found in tea that is said to help relieve stress.‡
Hops are high in bitter substances known as humulone and lupulone. These are thought to be responsible for the appetite-stimulating properties of hops. Hops also contain about 1–3% volatile oils. Hops have been shown to have mild sedative properties, although the mechanism is unclear.‡
Normally, the body secretes melatonin for several hours per night. Studies using melatonin for insomnia have reported good results. Many doctors suggest 1–3 mg of melatonin taken one to two hours bedtime. Adults with insomnia have been shown to have lower melatonin levels. Frequent travelers and shift workers are also likely to benefit from melatonin for the resynchronization of their sleep schedules.‡
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
One or two capsules one hour before bedtime.
Count
60 Capsules
Science
Clarinda N Sutanto, Wen Wei Loh, Jung Eun Kim, The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression, Nutrition Reviews, Volume 80, Issue 2, February 2022, Pages 306–316, https://doi.org/10.1093/nutrit/nuab027
Lindseth G, Helland B, Caspers J. The effects of dietary tryptophan on affective disorders. Arch Psychiatr Nurs. 2015 Apr;29(2):102-7. doi: 10.1016/j.apnu.2014.11.008. Epub 2014 Dec 9. PMID: 25858202; PMCID: PMC4393508.
Firk C, Markus CR. Mood and cortisol responses following tryptophan-rich hydrolyzed protein and acute stress in healthy subjects with high and low cognitive reactivity to depression. Clin Nutr. 2009 Jun;28(3):266-71. doi: 10.1016/j.clnu.2009.03.002. Epub 2009 Apr 3. PMID: 19345451.
Hogenelst K, Schoevers RA, Aan Het Rot M. The Effects of Tryptophan on Everyday Interpersonal Encounters and Social Cognitions in Individuals with a Family History of Depression. Int J Neuropsychopharmacol. 2015 Mar 2;18(8):pyv012. doi: 10.1093/ijnp/pyv012. PMID: 25733537; PMCID: PMC4571634.
Razeghi Jahromi S, Togha M, Ghorbani Z, Hekmatdoost A, Khorsha F, Rafiee P, Shirani P, Nourmohammadi M, Ansari H. The association between dietary tryptophan intake and migraine. Neurol Sci. 2019 Nov;40(11):2349-2355. doi: 10.1007/s10072-019-03984-3. Epub 2019 Jun 28. PMID: 31254181.
Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med. 2004 Jul-Aug;66(4):607-13. doi: 10.1097/01.psy.0000132877.72833.71. PMID: 15272110.
Kennedy DO, Little W, Haskell CF, Scholey AB. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res. 2006 Feb;20(2):96-102. doi: 10.1002/ptr.1787. PMID: 16444660.
Kennedy DO, Wake G, Savelev S, Tildesley NT, Perry EK, Wesnes KA, Scholey AB. Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology. 2003 Oct;28(10):1871-81. doi: 10.1038/sj.npp.1300230. PMID: 12888775.
Rao TP, Ozeki M, Juneja LR. In Search of a Safe Natural Sleep Aid. J Am Coll Nutr. 2015;34(5):436-47. doi: 10.1080/07315724.2014.926153. Epub 2015 Mar 11. PMID: 25759004.
Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390/nu11102362. PMID: 31623400; PMCID: PMC6836118.
Hidese S, Ota M, Wakabayashi C, Noda T, Ozawa H, Okubo T, Kunugi H. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr. 2017 Apr;29(2):72-79. doi: 10.1017/neu.2016.33. Epub 2016 Jul 11. PMID: 27396868.
Franco L, Sánchez C, Bravo R, Rodriguez A, Barriga C, Juánez JC. The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm. Acta Physiol Hung. 2012 Jun;99(2):133-9. doi: 10.1556/APhysiol.99.2012.2.6. PMID: 22849837.
Franco L, Sánchez C, Bravo R, Rodriguez A, Barriga C, Juánez JC. The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm. Acta Physiol Hung. 2012 Jun;99(2):133-9. doi: 10.1556/APhysiol.99.2012.2.6. PMID: 22849837.
Features :
Hygienic Product : Not Specified
Allergy : Not Specified
Description
Twilight Time™ is a unique formulation that helps to promote serotonin production in order to support a restful sleep.‡
L-Tryptophan is an essential amino acid that the body requires to synthesize proteins and specialized molecules such as the neurotransmitter serotonin. Serotonin appears to play significant roles in sleep, emotional moods, pain control, inflammation, intestinal peristalsis, and other body functions.‡
The terpenes, part of the pleasant smelling volatile oil from lemon balm, are thought to produce this herb’s relaxing and gas-relieving (carminative) effects.‡
L-Theanine is an amino acid found in tea that is said to help relieve stress.‡
Hops are high in bitter substances known as humulone and lupulone. These are thought to be responsible for the appetite-stimulating properties of hops. Hops also contain about 1–3% volatile oils. Hops have been shown to have mild sedative properties, although the mechanism is unclear.‡
Normally, the body secretes melatonin for several hours per night. Studies using melatonin for insomnia have reported good results. Many doctors suggest 1–3 mg of melatonin taken one to two hours bedtime. Adults with insomnia have been shown to have lower melatonin levels. Frequent travelers and shift workers are also likely to benefit from melatonin for the resynchronization of their sleep schedules.‡
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
One or two capsules one hour before bedtime.
Count
60 Capsules
Science
Clarinda N Sutanto, Wen Wei Loh, Jung Eun Kim, The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression, Nutrition Reviews, Volume 80, Issue 2, February 2022, Pages 306–316, https://doi.org/10.1093/nutrit/nuab027
Lindseth G, Helland B, Caspers J. The effects of dietary tryptophan on affective disorders. Arch Psychiatr Nurs. 2015 Apr;29(2):102-7. doi: 10.1016/j.apnu.2014.11.008. Epub 2014 Dec 9. PMID: 25858202; PMCID: PMC4393508.
Firk C, Markus CR. Mood and cortisol responses following tryptophan-rich hydrolyzed protein and acute stress in healthy subjects with high and low cognitive reactivity to depression. Clin Nutr. 2009 Jun;28(3):266-71. doi: 10.1016/j.clnu.2009.03.002. Epub 2009 Apr 3. PMID: 19345451.
Hogenelst K, Schoevers RA, Aan Het Rot M. The Effects of Tryptophan on Everyday Interpersonal Encounters and Social Cognitions in Individuals with a Family History of Depression. Int J Neuropsychopharmacol. 2015 Mar 2;18(8):pyv012. doi: 10.1093/ijnp/pyv012. PMID: 25733537; PMCID: PMC4571634.
Razeghi Jahromi S, Togha M, Ghorbani Z, Hekmatdoost A, Khorsha F, Rafiee P, Shirani P, Nourmohammadi M, Ansari H. The association between dietary tryptophan intake and migraine. Neurol Sci. 2019 Nov;40(11):2349-2355. doi: 10.1007/s10072-019-03984-3. Epub 2019 Jun 28. PMID: 31254181.
Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med. 2004 Jul-Aug;66(4):607-13. doi: 10.1097/01.psy.0000132877.72833.71. PMID: 15272110.
Kennedy DO, Little W, Haskell CF, Scholey AB. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res. 2006 Feb;20(2):96-102. doi: 10.1002/ptr.1787. PMID: 16444660.
Kennedy DO, Wake G, Savelev S, Tildesley NT, Perry EK, Wesnes KA, Scholey AB. Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology. 2003 Oct;28(10):1871-81. doi: 10.1038/sj.npp.1300230. PMID: 12888775.
Rao TP, Ozeki M, Juneja LR. In Search of a Safe Natural Sleep Aid. J Am Coll Nutr. 2015;34(5):436-47. doi: 10.1080/07315724.2014.926153. Epub 2015 Mar 11. PMID: 25759004.
Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390/nu11102362. PMID: 31623400; PMCID: PMC6836118.
Hidese S, Ota M, Wakabayashi C, Noda T, Ozawa H, Okubo T, Kunugi H. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr. 2017 Apr;29(2):72-79. doi: 10.1017/neu.2016.33. Epub 2016 Jul 11. PMID: 27396868.
Franco L, Sánchez C, Bravo R, Rodriguez A, Barriga C, Juánez JC. The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm. Acta Physiol Hung. 2012 Jun;99(2):133-9. doi: 10.1556/APhysiol.99.2012.2.6. PMID: 22849837.
Franco L, Sánchez C, Bravo R, Rodriguez A, Barriga C, Juánez JC. The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm. Acta Physiol Hung. 2012 Jun;99(2):133-9. doi: 10.1556/APhysiol.99.2012.2.6. PMID: 22849837.
