Pro-Antho Forte® is a flavonoid antioxidant complex designed to provide support of the cardiovascular system through potent antioxidants, procyanidins, and resveratrol.‡
Oligopin® is standardized to contain at least 67% procyanidins—a subclass of polyphenols similar to those found in berries and citrus fruits. Procyanidins from Oligopin® are metabolized to catechin, caffeic acid, taxifolin, ferulic acid, and a unique compound known as δ-(3,4-dihydroxy-phenyl)-γ-valerolactone. Oligopin® also contains a number of other polyphenols and organic acids, such as cinnamic acids. There are over 400 scientific publications supporting the benefits of this plant extract, especially for cardiovascular function.‡
In a 6-week study in 25 healthy adult subjects who took 150 mg of French maritime pine bark extract daily, a healthy balance of cardiovascular lipids occurred. The same study also found that plasma oxygen radical absorbance capacity (ORAC) was significantly elevated after four weeks.‡
Moreover, nitric oxide (NO) is imperative for proper vasodilation (blood vessel expansion/relaxation), and thus, healthy blood flow and blood pressure. Procyanidins, which are abundant in Oligopin®, have been shown to promote blood flow by increasing NO production, as well as supporting healthy blood pressure already in the healthy range.‡
Resveratrol is reported to have health benefits including anticarcinogenic effects and protection against cardiovascular disease. ‡
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
One vegetable capsule twice daily with meals.
Count
60 Vegetable Capsules
Science
Javadi F, Ahmadzadeh A, Eghtesadi S, Aryaeian N, Zabihiyeganeh M, Rahimi Foroushani A, Jazayeri S. The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial. J Am Coll Nutr. 2017 Jan;36(1):9-15. doi: 10.1080/07315724.2016.1140093. Epub 2016 Oct 6. PMID: 27710596.
Leyva-López N, Gutierrez-Grijalva EP, Ambriz-Perez DL, Heredia JB. Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases. Int J Mol Sci. 2016 Jun 9;17(6):921. doi: 10.3390/ijms17060921. PMID: 27294919; PMCID: PMC4926454.
Shishehbor F, Behroo L, Ghafouriyan Broujerdnia M, Namjoyan F, Latifi SM. Quercetin effectively quells peanut-induced anaphylactic reactions in the peanut sensitized rats. Iran J Allergy Asthma Immunol. 2010 Mar;9(1):27-34. PMID: 20548131.
Chen CK, Pace-Asciak CR. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen Pharmacol. 1996 Mar;27(2):363-6. doi: 10.1016/0306-3623(95)02001-2. PMID: 8919657.
Chacko SM, Thambi PT, Kuttan R, Nishigaki I. Beneficial effects of green tea: a literature review. Chin Med. 2010 Apr 6;5:13. doi: 10.1186/1749-8546-5-13. PMID: 20370896; PMCID: PMC2855614.
Eng QY, Thanikachalam PV, Ramamurthy S. Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases. J Ethnopharmacol. 2018 Jan 10;210:296-310. doi: 10.1016/j.jep.2017.08.035. Epub 2017 Aug 31. PMID: 28864169.
Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med. 2010 Dec 1;49(11):1603-16. doi: 10.1016/j.freeradbiomed.2010.09.006. Epub 2010 Sep 16. PMID: 20840865; PMCID: PMC2990475.
Shinichi Kuriyama, The Relation between Green Tea Consumption and Cardiovascular Disease as Evidenced by Epidemiological Studies, The Journal of Nutrition, Volume 138, Issue 8, August 2008, Pages 1548S–1553S, https://doi.org/10.1093/jn/138.8.1548S
Elham Navval-Esfahlan, Maryam Rafraf, Somayyeh Asghari, Hossein Imani, Mohammad Asghari-Jafarabadi, Sanaz Karimi-Avval, Effect of French maritime pine bark extract supplementation on metabolic status and serum vascular cell adhesion molecule-1 levels in patients with type 2 diabetes and microalbuminuria, Complementary Therapies in Medicine, Volume 58,, 102689, ISSN 0965-2299, https://doi.org/10.1016/j.ctim.2021.102689
Majidi Z, Ansari M, Maghbooli Z, Ghasemi A, Ebrahimi SSS, Hossein-Nezhad A, Emamgholipour S. Oligopin® Supplementation Mitigates Oxidative Stress in Postmenopausal Women with Osteopenia: A Randomized, Double-blind, Placebo-Controlled Trial. Phytomedicine. 2021 Jan;81:153417. doi: 10.1016/j.phymed.2020.153417. Epub 2020 Nov 19. PMID: 33250314.
Fine AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev. 2000 Apr;5(2):144-51. PMID: 10767669.
Asbaghi O, Nazarian B, Reiner Ž, Amirani E, Kolahdooz F, Chamani M, Asemi Z. The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2020 Feb;34(2):239-253. doi: 10.1002/ptr.6518. Epub 2019 Dec 26. Erratum in: Phytother Res. 2022 Mar;36(3):1413. PMID: 31880030.
Meng X, Zhou J, Zhao CN, Gan RY, Li HB. Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review. Foods. 2020 Mar 14;9(3):340. doi: 10.3390/foods9030340. PMID: 32183376; PMCID: PMC7143620.
Features :
Hygienic Product : Not Specified
Allergy : Not Specified
Description
Pro-Antho Forte® is a flavonoid antioxidant complex designed to provide support of the cardiovascular system through potent antioxidants, procyanidins, and resveratrol.‡
Oligopin® is standardized to contain at least 67% procyanidins—a subclass of polyphenols similar to those found in berries and citrus fruits. Procyanidins from Oligopin® are metabolized to catechin, caffeic acid, taxifolin, ferulic acid, and a unique compound known as δ-(3,4-dihydroxy-phenyl)-γ-valerolactone. Oligopin® also contains a number of other polyphenols and organic acids, such as cinnamic acids. There are over 400 scientific publications supporting the benefits of this plant extract, especially for cardiovascular function.‡
In a 6-week study in 25 healthy adult subjects who took 150 mg of French maritime pine bark extract daily, a healthy balance of cardiovascular lipids occurred. The same study also found that plasma oxygen radical absorbance capacity (ORAC) was significantly elevated after four weeks.‡
Moreover, nitric oxide (NO) is imperative for proper vasodilation (blood vessel expansion/relaxation), and thus, healthy blood flow and blood pressure. Procyanidins, which are abundant in Oligopin®, have been shown to promote blood flow by increasing NO production, as well as supporting healthy blood pressure already in the healthy range.‡
Resveratrol is reported to have health benefits including anticarcinogenic effects and protection against cardiovascular disease. ‡
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
One vegetable capsule twice daily with meals.
Count
60 Vegetable Capsules
Science
Javadi F, Ahmadzadeh A, Eghtesadi S, Aryaeian N, Zabihiyeganeh M, Rahimi Foroushani A, Jazayeri S. The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial. J Am Coll Nutr. 2017 Jan;36(1):9-15. doi: 10.1080/07315724.2016.1140093. Epub 2016 Oct 6. PMID: 27710596.
Leyva-López N, Gutierrez-Grijalva EP, Ambriz-Perez DL, Heredia JB. Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases. Int J Mol Sci. 2016 Jun 9;17(6):921. doi: 10.3390/ijms17060921. PMID: 27294919; PMCID: PMC4926454.
Shishehbor F, Behroo L, Ghafouriyan Broujerdnia M, Namjoyan F, Latifi SM. Quercetin effectively quells peanut-induced anaphylactic reactions in the peanut sensitized rats. Iran J Allergy Asthma Immunol. 2010 Mar;9(1):27-34. PMID: 20548131.
Chen CK, Pace-Asciak CR. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen Pharmacol. 1996 Mar;27(2):363-6. doi: 10.1016/0306-3623(95)02001-2. PMID: 8919657.
Chacko SM, Thambi PT, Kuttan R, Nishigaki I. Beneficial effects of green tea: a literature review. Chin Med. 2010 Apr 6;5:13. doi: 10.1186/1749-8546-5-13. PMID: 20370896; PMCID: PMC2855614.
Eng QY, Thanikachalam PV, Ramamurthy S. Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases. J Ethnopharmacol. 2018 Jan 10;210:296-310. doi: 10.1016/j.jep.2017.08.035. Epub 2017 Aug 31. PMID: 28864169.
Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med. 2010 Dec 1;49(11):1603-16. doi: 10.1016/j.freeradbiomed.2010.09.006. Epub 2010 Sep 16. PMID: 20840865; PMCID: PMC2990475.
Shinichi Kuriyama, The Relation between Green Tea Consumption and Cardiovascular Disease as Evidenced by Epidemiological Studies, The Journal of Nutrition, Volume 138, Issue 8, August 2008, Pages 1548S–1553S, https://doi.org/10.1093/jn/138.8.1548S
Elham Navval-Esfahlan, Maryam Rafraf, Somayyeh Asghari, Hossein Imani, Mohammad Asghari-Jafarabadi, Sanaz Karimi-Avval, Effect of French maritime pine bark extract supplementation on metabolic status and serum vascular cell adhesion molecule-1 levels in patients with type 2 diabetes and microalbuminuria, Complementary Therapies in Medicine, Volume 58,, 102689, ISSN 0965-2299, https://doi.org/10.1016/j.ctim.2021.102689
Majidi Z, Ansari M, Maghbooli Z, Ghasemi A, Ebrahimi SSS, Hossein-Nezhad A, Emamgholipour S. Oligopin® Supplementation Mitigates Oxidative Stress in Postmenopausal Women with Osteopenia: A Randomized, Double-blind, Placebo-Controlled Trial. Phytomedicine. 2021 Jan;81:153417. doi: 10.1016/j.phymed.2020.153417. Epub 2020 Nov 19. PMID: 33250314.
Fine AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev. 2000 Apr;5(2):144-51. PMID: 10767669.
Asbaghi O, Nazarian B, Reiner Ž, Amirani E, Kolahdooz F, Chamani M, Asemi Z. The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2020 Feb;34(2):239-253. doi: 10.1002/ptr.6518. Epub 2019 Dec 26. Erratum in: Phytother Res. 2022 Mar;36(3):1413. PMID: 31880030.
Meng X, Zhou J, Zhao CN, Gan RY, Li HB. Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review. Foods. 2020 Mar 14;9(3):340. doi: 10.3390/foods9030340. PMID: 32183376; PMCID: PMC7143620.
