Natto is a traditional Japanese food made from soybeans fermented with a specific strain of bacteria, and has been found in Japanese foods for over 1,000 years. Contained within natto is a very potent enzyme called nattokinase.‡
Nattokinase has been extensively studied in Japan, Korea, and China for its powerful support of the healthy blood clot-dissolving properties. Compared to other enzymes, nattokinase has the highest fibrinolytic (anti-clotting) activity in comparison to other enzymes. As a result of these characteristics, nattokinase has been studied for its benefits in support of cardiovascular health, blood pressure in healthy levels, blood flow, and support of healthy levels of cholesterol.‡
Natto NSK Mega from Progressive Laboratories contains high-potency nattokinase from NSK-SD®, a highly researched extract from JCR Pharmaceuticals of Kobe, Japan.‡
In an animal study conducted by Biotechnology Research Laboratories and JCR Pharmaceuticals, nattokinase promoted healthy blood flow. Furthermore, researchers from JCR Pharmaceuticals, Oklahoma State University and Miyazaki Medical College indicated that nattokinase supports healthy clotting function compared to placebo. In 1995, scientists at the Miyazaki Medical College and Kurashiki University in Japan demonstrated the potential for nattokinase to support blood vessel health in human subjects.‡
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
One vegetable capsule twice daily with 8-10 ounces of water. Take with or without food.
Count
60 Vegetable Capsules
Science
Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84(3):139-43. doi: 10.1159/000205051. PMID: 2123064.
Suzuki Y, Kondo K, Matsumoto Y, Zhao BQ, Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003 Jul 25;73(10):1289-98. doi: 10.1016/s0024-3205(03)00426-0. PMID: 12850244.
Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation with fermented soybeans suppresses intimal thickening. Nutrition. 2003 Mar;19(3):261-4. doi: 10.1016/s0899-9007(02)00853-5. PMID: 12620531.
Weng Y, Yao J, Sparks S, Wang KY. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017 Feb 28;18(3):523. doi: 10.3390/ijms18030523. PMID: 28264497; PMCID: PMC5372539.
Kurosawa Y, Nirengi S, Homma T, Esaki K, Ohta M, Clark JF, Hamaoka T. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015 Jun 25;5:11601. doi: 10.1038/srep11601. PMID: 26109079; PMCID: PMC4479826.
Hsia CH, Shen MC, Lin JS, Wen YK, Hwang KL, Cham TM, Yang NC. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009 Mar;29(3):190-6. doi: 10.1016/j.nutres.2009.01.009. PMID: 19358933.
Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomarker Insights. 2018;13. doi:10.1177/1177271918785130
Nagata C, Wada K, Tamura T, Konishi K, Goto Y, Koda S, Kawachi T, Tsuji M, Nakamura K. Dietary soy and natto intake and cardiovascular disease mortality in Japanese adults: the Takayama study. Am J Clin Nutr. 2017 Feb;105(2):426-431. doi: 10.3945/ajcn.116.137281. Epub 2016 Dec 7. PMID: 27927636.
Natto is a traditional Japanese food made from soybeans fermented with a specific strain of bacteria, and has been found in Japanese foods for over 1,000 years. Contained within natto is a very potent enzyme called nattokinase.‡
Nattokinase has been extensively studied in Japan, Korea, and China for its powerful support of the healthy blood clot-dissolving properties. Compared to other enzymes, nattokinase has the highest fibrinolytic (anti-clotting) activity in comparison to other enzymes. As a result of these characteristics, nattokinase has been studied for its benefits in support of cardiovascular health, blood pressure in healthy levels, blood flow, and support of healthy levels of cholesterol.‡
Natto NSK Mega from Progressive Laboratories contains high-potency nattokinase from NSK-SD®, a highly researched extract from JCR Pharmaceuticals of Kobe, Japan.‡
In an animal study conducted by Biotechnology Research Laboratories and JCR Pharmaceuticals, nattokinase promoted healthy blood flow. Furthermore, researchers from JCR Pharmaceuticals, Oklahoma State University and Miyazaki Medical College indicated that nattokinase supports healthy clotting function compared to placebo. In 1995, scientists at the Miyazaki Medical College and Kurashiki University in Japan demonstrated the potential for nattokinase to support blood vessel health in human subjects.‡
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
One vegetable capsule twice daily with 8-10 ounces of water. Take with or without food.
Count
60 Vegetable Capsules
Science
Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84(3):139-43. doi: 10.1159/000205051. PMID: 2123064.
Suzuki Y, Kondo K, Matsumoto Y, Zhao BQ, Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003 Jul 25;73(10):1289-98. doi: 10.1016/s0024-3205(03)00426-0. PMID: 12850244.
Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation with fermented soybeans suppresses intimal thickening. Nutrition. 2003 Mar;19(3):261-4. doi: 10.1016/s0899-9007(02)00853-5. PMID: 12620531.
Weng Y, Yao J, Sparks S, Wang KY. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017 Feb 28;18(3):523. doi: 10.3390/ijms18030523. PMID: 28264497; PMCID: PMC5372539.
Kurosawa Y, Nirengi S, Homma T, Esaki K, Ohta M, Clark JF, Hamaoka T. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015 Jun 25;5:11601. doi: 10.1038/srep11601. PMID: 26109079; PMCID: PMC4479826.
Hsia CH, Shen MC, Lin JS, Wen YK, Hwang KL, Cham TM, Yang NC. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009 Mar;29(3):190-6. doi: 10.1016/j.nutres.2009.01.009. PMID: 19358933.
Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomarker Insights. 2018;13. doi:10.1177/1177271918785130
Nagata C, Wada K, Tamura T, Konishi K, Goto Y, Koda S, Kawachi T, Tsuji M, Nakamura K. Dietary soy and natto intake and cardiovascular disease mortality in Japanese adults: the Takayama study. Am J Clin Nutr. 2017 Feb;105(2):426-431. doi: 10.3945/ajcn.116.137281. Epub 2016 Dec 7. PMID: 27927636.
