Legs on Edge® is a formula designed to help support the easing of mild muscle cramps and tension typically found in the extremities and predominantly in the night-time or after periods of physical exertion. Legs on Edge® is based on a combination of electrolytes, vitamins and herbs which have been shown to support normal neural function to prevent cramping or tension.‡
Calcium, magnesium, and potassium are minerals which are electrolytes and important to maintaining normal muscle contractions. Iron also has been shown to play an important role.‡
Folic acid is included as folate deficiency has been shown to play a role in healthy muscle contractions. Horse chestnut extract is provided for its support of healthy blood flow and veins, which helps to transport oxygen and electrolytes to the extremities.‡
Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose call a doctor or poison control center immediately.
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
Take one to three capsules one hour before bedtime.
Count
60 Vegetable Capsules
Science
Jadidi A, Rezaei Ashtiani A, Khanmohamadi Hezaveh A, Aghaepour SM. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. BMC Complement Med Ther. 2022 Dec 31;23(1):1. doi: 10.1186/s12906-022-03814-8. PMID: 36587225; PMCID: PMC9804944.
Practice guideline summary: Treatment of restless legs syndrome in adults. Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. John W. Winkelman, Melissa J. Armstrong, Richard P. Allen, K. Ray Chaudhuri, William Ondo, Claudia Trenkwalder, Phyllis C. Zee, Gary S. Gronseth, David Gloss, Theresa Zesiewicz. Neurology Dec 2016, 87 (24) 2585-2593; DOI: 10.1212/WNL.0000000000003388
Wali, S., Shukr, A., Boudal, A. et al. The effect of vitamin D supplements on the severity of restless legs syndrome. Sleep Breath 19, 579–583 (2015). https://doi.org/10.1007/s11325-014-1049-y
Dadashpour S, Hajmiri MS, Roshani D. Effect of intravenous vitamin C supplementation on the quality of sleep, itching and restless leg syndrome in patients undergoing hemodialysis; A double-blind randomized clinical trial. J Nephropharmacol. 2018;7(2):131-136.
Mansur A, Castillo PR, Rocha Cabrero F, et al. Restless Legs Syndrome. [Updated 2023 Feb 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430878/
Guo S, Huang J, Jiang H, Han C, Li J, Xu X, Zhang G, Lin Z, Xiong N, Wang T. Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management. Front Aging Neurosci. 2017 Jun 2;9:171. doi: 10.3389/fnagi.2017.00171. PMID: 28626420; PMCID: PMC5454050.
Sagheb MM, Dormanesh B, Fallahzadeh MK, Akbari H, Sohrabi Nazari S, Heydari ST, Behzadi S. Efficacy of vitamins C, E, and their combination for treatment of restless legs syndrome in hemodialysis patients: a randomized, double-blind, placebo-controlled trial. Sleep Med. 2012 May;13(5):542-5. doi: 10.1016/j.sleep.2011.11.010. Epub 2012 Feb 7. PMID: 22317944.
Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2012 Nov 14;11(11):CD003230. doi: 10.1002/14651858.CD003230.pub4. PMID: 23152216; PMCID: PMC7144685.
Methlie CB, Schjøtt J. Hestekastanje – naturlegemiddel mot venøs insuffisiens [Horse chestnut–remedy for chronic venous insufficiency]. Tidsskr Nor Laegeforen. 2009 Feb 26;129(5):420-2. Norwegian. doi: 10.4045/tidsskr.09.33871. PMID: 19247403.
Suter A, Bommer S, Rechner J. Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies. Adv Ther. 2006 Jan-Feb;23(1):179-90. doi: 10.1007/BF02850359. PMID: 16644618.
Features :
Hygienic Product : Not Specified
Allergy : Not Specified
Legs on Edge® - 449
Description
Legs on Edge® is a formula designed to help support the easing of mild muscle cramps and tension typically found in the extremities and predominantly in the night-time or after periods of physical exertion. Legs on Edge® is based on a combination of electrolytes, vitamins and herbs which have been shown to support normal neural function to prevent cramping or tension.‡
Calcium, magnesium, and potassium are minerals which are electrolytes and important to maintaining normal muscle contractions. Iron also has been shown to play an important role.‡
Folic acid is included as folate deficiency has been shown to play a role in healthy muscle contractions. Horse chestnut extract is provided for its support of healthy blood flow and veins, which helps to transport oxygen and electrolytes to the extremities.‡
Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose call a doctor or poison control center immediately.
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
Take one to three capsules one hour before bedtime.
Count
60 Vegetable Capsules
Science
Jadidi A, Rezaei Ashtiani A, Khanmohamadi Hezaveh A, Aghaepour SM. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. BMC Complement Med Ther. 2022 Dec 31;23(1):1. doi: 10.1186/s12906-022-03814-8. PMID: 36587225; PMCID: PMC9804944.
Practice guideline summary: Treatment of restless legs syndrome in adults. Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. John W. Winkelman, Melissa J. Armstrong, Richard P. Allen, K. Ray Chaudhuri, William Ondo, Claudia Trenkwalder, Phyllis C. Zee, Gary S. Gronseth, David Gloss, Theresa Zesiewicz. Neurology Dec 2016, 87 (24) 2585-2593; DOI: 10.1212/WNL.0000000000003388
Wali, S., Shukr, A., Boudal, A. et al. The effect of vitamin D supplements on the severity of restless legs syndrome. Sleep Breath 19, 579–583 (2015). https://doi.org/10.1007/s11325-014-1049-y
Dadashpour S, Hajmiri MS, Roshani D. Effect of intravenous vitamin C supplementation on the quality of sleep, itching and restless leg syndrome in patients undergoing hemodialysis; A double-blind randomized clinical trial. J Nephropharmacol. 2018;7(2):131-136.
Mansur A, Castillo PR, Rocha Cabrero F, et al. Restless Legs Syndrome. [Updated 2023 Feb 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430878/
Guo S, Huang J, Jiang H, Han C, Li J, Xu X, Zhang G, Lin Z, Xiong N, Wang T. Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management. Front Aging Neurosci. 2017 Jun 2;9:171. doi: 10.3389/fnagi.2017.00171. PMID: 28626420; PMCID: PMC5454050.
Sagheb MM, Dormanesh B, Fallahzadeh MK, Akbari H, Sohrabi Nazari S, Heydari ST, Behzadi S. Efficacy of vitamins C, E, and their combination for treatment of restless legs syndrome in hemodialysis patients: a randomized, double-blind, placebo-controlled trial. Sleep Med. 2012 May;13(5):542-5. doi: 10.1016/j.sleep.2011.11.010. Epub 2012 Feb 7. PMID: 22317944.
Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2012 Nov 14;11(11):CD003230. doi: 10.1002/14651858.CD003230.pub4. PMID: 23152216; PMCID: PMC7144685.
Methlie CB, Schjøtt J. Hestekastanje – naturlegemiddel mot venøs insuffisiens [Horse chestnut–remedy for chronic venous insufficiency]. Tidsskr Nor Laegeforen. 2009 Feb 26;129(5):420-2. Norwegian. doi: 10.4045/tidsskr.09.33871. PMID: 19247403.
Suter A, Bommer S, Rechner J. Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies. Adv Ther. 2006 Jan-Feb;23(1):179-90. doi: 10.1007/BF02850359. PMID: 16644618.
