5-Hydroxy L-Tryptophan (5HTP) - 833

Description

5-Hydroxytryptophan (5-HTP) is an intermediate in the synthesis of the tryptophan and then to serotonin.  Clinical studies suggest that 5-HTP supports healthy serotonin levels, which is an important neurotransmitter involved in the regulation of endocrine and brain activity responsible for emotion, appetite and sleep/wake cycles.  In the body, 5-HTP converts to serotonin.‡

Supplementation with 5-Hydroxy L-Tryptophan (5HTP) supports emotional well-being, acts as an appetite suppressant, supports a healthy mood.‡

WARNING: Do not take with MAO inhibitors or anti-depressants.

Warning:  If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.

‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.

Ingredients

Dosage

One capsule daily.

Count

30 Capsule

Science

Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020 Dec 26;22(1):181. doi: 10.3390/ijms22010181. PMID: 33375373; PMCID: PMC7796270.

Bruni O, Ferri R, Miano S, Verrillo E. L -5-Hydroxytryptophan treatment of sleep terrors in children. Eur J Pediatr. 2004 Jul;163(7):402-7. doi: 10.1007/s00431-004-1444-7. Epub 2004 May 14. PMID: 15146330.

Cangiano C, Ceci F, Cascino A, Del Ben M, Laviano A, Muscaritoli M, Antonucci F, Rossi-Fanelli F. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr. 1992 Nov;56(5):863-7. doi: 10.1093/ajcn/56.5.863. PMID: 1384305.

Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006 Jul 20;51(2):239-49. doi: 10.1016/j.neuron.2006.06.004. PMID: 16846858.

Zhou L, Williams T, Lachey JL, Kishi T, Cowley MA, Heisler LK. Serotonergic pathways converge upon central melanocortin systems to regulate energy balance. Peptides. 2005 Oct;26(10):1728-32. doi: 10.1016/j.peptides.2004.12.028. PMID: 15993514.

Nautiyal KM, Hen R. Serotonin receptors in depression: from A to B. F1000Res. 2017 Feb 9;6:123. doi: 10.12688/f1000research.9736.1. PMID: 28232871; PMCID: PMC5302148.

Kious BM, Sabic H, Sung YH, Kondo DG, Renshaw P. An Open-Label Pilot Study of Combined Augmentation With Creatine Monohydrate and 5-Hydroxytryptophan for Selective Serotonin Reuptake Inhibitor- or Serotonin-Norepinephrine Reuptake Inhibitor-Resistant Depression in Adult Women. J Clin Psychopharmacol. 2017 Oct;37(5):578-583. doi: 10.1097/JCP.0000000000000754. PMID: 28787372; PMCID: PMC5578880.

Hong KB, Park Y, Suh HJ. Sleep-promoting effects of a GABA/5-HTP mixture: Behavioral changes and neuromodulation in an invertebrate model. Life Sci. 2016 Apr 1;150:42-9. doi: 10.1016/j.lfs.2016.02.086. Epub 2016 Feb 26. PMID: 26921634.

Turner EH, Loftis JM, Blackwell AD. Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacol Ther. 2006 Mar;109(3):325-38. doi: 10.1016/j.pharmthera.2005.06.004. Epub 2005 Jul 14. PMID: 16023217.

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