{"product_id":"vitamin-d3-k2","title":"Vitamin D3 \u0026 K2","description":"\u003ch5\u003e\u003cspan\u003eDescription\u003c\/span\u003e\u003c\/h5\u003e\u003cdiv class=\"accordion-attribute accordion-attribute-benefits-features\"\u003e\n\u003cul\u003e\n\u003cli\u003ePromotes healthy calcium utilization to maintain bone health\u003csup\u003e‡\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSupports vascular tissue to support healthy arterial calcium balance and vascular elasticity\u003csup\u003e‡\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSupports immune function with vitamin D\u003csub\u003e3\u003c\/sub\u003e\u003csup\u003e‡\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eProvides vitamin D\u003csub\u003e3\u003c\/sub\u003e and vitamin K\u003csub\u003e2\u003c\/sub\u003e in one convenient capsule\u003c\/li\u003e\n\u003cli\u003e100 mcg of biologically active all-trans vitamin K\u003csub\u003e2\u003c\/sub\u003e (MK-7) per capsule \u003c\/li\u003e\n\u003cli\u003eMade with hypoallergenic ingredients\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\u003cdiv class=\"accordion-attribute-container\"\u003e\n\u003cdiv class=\"accordion-attribute accordion-attribute-indications\"\u003e\n\u003ch2\u003eIndications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAges 18 and up\u003c\/li\u003e\n\u003cli\u003eBone and vascular health support\u003csup\u003e‡\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"accordion-attribute accordion-attribute-suggested_use\"\u003e\n\u003ch2\u003eSuggested Use\u003c\/h2\u003e\n\u003cp\u003eAs a dietary supplement,  take 1 capsule daily,  with a meal or as directed by a health professional.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e \u003cdiv class=\"accordion-attribute accordion-attribute-verifiable_science\"\u003e\n\u003ch2\u003eVerifiable Science\u003c\/h2\u003eVitamin K\u003csub\u003e2\u003c\/sub\u003e (menaquinone-7) is a fat-soluble nutrient with an important role in maintaining arterial calcium balance and vascular elasticity.\u003csup\u003e1-12\u003c\/sup\u003e In a systematic review involving five studies,  higher intakes of vitamin K\u003csub\u003e2\u003c\/sub\u003e were associated with cardiovascular health.\u003csup\u003e10\u003c\/sup\u003e  In an observational study involving 564 postmenopausal women,  higher intake of vitamin K\u003csub\u003e2\u003c\/sub\u003e was associated with calcium balance in the vascular tissue.\u003csup\u003e8\u003c\/sup\u003e  One of the primary functions of vitamin K\u003csub\u003e2\u003c\/sub\u003e is to support the carboxylation of matrix Gla-protein (MGP),  a key protein involved in calcium balance.\u003csup\u003e11\u003c\/sup\u003e Accordingly,  several studies indicate that Vitamin K\u003csub\u003e2\u003c\/sub\u003e also supports proper utilization of calcium in bone. Clinical research indicates that obtaining adequate amounts helps to maintain bone health.\u003csup\u003e1-6\u003c\/sup\u003e Vitamin K\u003csub\u003e2\u003c\/sub\u003e and vitamin D\u003csub\u003e3\u003c\/sub\u003e both participate in the regulation of osteocalcin,  a biomarker of bone formation.\u003csup\u003e1, 13‡\u003c\/sup\u003e\n\u003c\/div\u003e\u003cdiv class=\"accordion-attribute accordion-attribute-references\"\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eGropper SAS,  Smith JL,  Groff JL. Advanced Nutrition and Human Metabolism. 5th Ed. Chapter 10,  pp. 412-414. Wadsworth\/Cengage Learning,  Australia. c.2009.\u003c\/li\u003e\n\u003cli\u003eEl Borolossy R,  El-Farsy MS. Eur J Clin Nutr. 2022 Jun;76(6):848-854. \u003c\/li\u003e\n\u003cli\u003eQiu C,  Zheng H,  Tao H,  et al. Mol Cell Biochem. 2017 Sep;433(1-2):149-159.  \u003c\/li\u003e\n\u003cli\u003eYamaguchi M,  Sugimoto E,  Hachiya S. Mol Cell Biochem. 2001 Jul;223(1-2):131-7.  \u003c\/li\u003e\n\u003cli\u003eZhang Y,  Liu Z,  Duan L,  et al. Calcif Tissue Int. 2020 May;106(5):476-485. \u003c\/li\u003e\n\u003cli\u003eKnapen MH,  Drummen NE,  Smit E,  et al. Osteoporos Int. 2013 Sep;24(9):2499-507.   \u003c\/li\u003e\n\u003cli\u003eKnapen MH,  Braam LA,  Drummen NE,  et al. Thromb Haemost. 2015 May;113(5):1135-44.  \u003c\/li\u003e\n\u003cli\u003eBeulens JW,  Bots ML,  Atsma F,  et al. Atherosclerosis. 2009 Apr;203(2):489-93.\u003c\/li\u003e\n\u003cli\u003eMansour AG,  Hariri E,  Daaboul Y,  et al. J Am Soc Hypertens. 2017 Sep;11(9):589-597.  \u003c\/li\u003e\n\u003cli\u003eRees K,  Guraewal S,  Wong YL,  et al. Maturitas. 2010 Oct;67(2):121-8.\u003c\/li\u003e\n\u003cli\u003eDalmeijer GW,  van der Schouw YT,  Magdeleyns E. Atherosclerosis. 2012 Dec;225(2):397-402.   \u003c\/li\u003e\n\u003cli\u003eVermeer C and Vik H. Vascul Dis Ther. 2020;5: doi: 10.15761\/VDT.1000179.\u003c\/li\u003e\n\u003cli\u003eGigante A,  Brugè F,  Cecconi S,  et al. J Tissue Eng Regen Med. 2015 Jun;9(6):691-701.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/div\u003e\u003ch5\u003e\u003cspan\u003eSpecifications\u003c\/span\u003e\u003c\/h5\u003e\u003cul\u003e\n\u003cli\u003eUPC: Not Specified\u003c\/li\u003e\n\u003cli\u003eGTIN\/ITF Barcode: Not Specified\u003c\/li\u003e\n\u003cli\u003eUnits of Measure: Not Specified\u003c\/li\u003e\n\u003cli\u003eOverall Product Length: Not Specified in\u003c\/li\u003e\n\u003cli\u003eOverall Product Width: Not Specified in\u003c\/li\u003e\n\u003cli\u003eOverall Product Height: Not Specified in\u003c\/li\u003e\n\u003cli\u003eWeight Capacity: Not Specified lbs\u003c\/li\u003e\n\u003cli\u003eActual Product Weight: 0.25\u003c\/li\u003e\n\u003cli\u003eProduct Assembly: Not Specified\u003c\/li\u003e\n\u003cli\u003eProduct Installation: Not Specified\u003c\/li\u003e\n\u003cli\u003eCountry of Origin: Not Specified\u003c\/li\u003e\n\u003cli\u003eCase QTY: Not Specified\/case\u003c\/li\u003e\n\u003cli\u003eCase Weight: Not Specified\u003c\/li\u003e\n\u003cli\u003eShips Via Freight: Not Specified\u003c\/li\u003e\n\u003cli\u003eProposition 65 Warning: Not Specified\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Save On LLC","offers":[{"title":"60 capsules","offer_id":48268539920576,"sku":"VDK46","price":19.5,"currency_code":"USD","in_stock":true},{"title":"120 capsules","offer_id":48268542312640,"sku":"VDK41","price":35.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1403\/8729\/files\/1778093283751.avif?v=1778093286","url":"https:\/\/tensnet.com\/products\/vitamin-d3-k2","provider":"TENSnet","version":"1.0","type":"link"}