{"product_id":"nrf2-detox","title":"Nrf2 Detox","description":"\u003ch5\u003e\u003cspan\u003eDescription\u003c\/span\u003e\u003c\/h5\u003e\u003cdiv class=\"accordion-attribute accordion-attribute-benefits-features\"\u003e\n\u003cul\u003e\n\u003cli\u003eSupports phase II enzyme function in the gut and liver,  supporting toxin elimination\u003csup\u003e‡\u003c\/sup\u003e \u003c\/li\u003e\n\u003cli\u003ePromotes the activity of Nrf2 to support detoxification and protection against oxidative stress\u003csup\u003e‡\u003c\/sup\u003e \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eBioavailable,  clinically studied Setria\u003csup\u003e®\u003c\/sup\u003e glutathione\u003c\/li\u003e\n\u003cli\u003eStandardized to contain a minimum of 1, 000 mcg sulforaphane\u003c\/li\u003e\n\u003cli\u003ePart of the PureGenomics\u003csup\u003e®\u003c\/sup\u003e product line\u003c\/li\u003e\n\u003cli\u003eMade with high-quality vegan ingredients backed by verifiable science\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\u003cdiv class=\"accordion-attribute-container\"\u003e\n\u003cdiv class=\"accordion-attribute accordion-attribute-indications\"\u003e\n\u003ch2\u003eIndications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAges 18 and up\u003c\/li\u003e\n\u003cli\u003eCellular detoxification and antioxidant protection\u003csup\u003e‡\u003c\/sup\u003e \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"accordion-attribute accordion-attribute-suggested_use\"\u003e\n\u003ch2\u003eSuggested Use\u003c\/h2\u003e\n\u003cp\u003eAs a dietary supplement,  take 1 capsule,  1-3 times daily,  with meals.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e \u003cdiv class=\"accordion-attribute accordion-attribute-verifiable_science\"\u003e\n\u003ch2\u003eVerifiable Science\u003c\/h2\u003eCruciferous vegetables of the Brassica family have long been recognized for their ability to support detoxification,  thereby maintaining healthy cells and tissues. Cruciferous vegetables,  like broccoli,  cauliflower,  Brussels sprouts and kale,  are the richest sources of glucosinolates,  which are considered to be the most bioactive constituents. Glucosinolates are converted in the body to isothiocyanates after they are ingested and hydrolyzed. The isothiocyanate sulforaphane is one of the most effective activators of phase II detoxification,  which occurs primarily in the gut and the liver.\u003csup\u003e1, 2\u003c\/sup\u003e Sulforaphane and resveratrol promote the activity of nuclear factor erythroid 2-related factor 2 (Nrf2),  a transcription factor that supports robust,  long-lasting expression of numerous genes responsible for phase II detoxification and protection against oxidative stress.\u003csup\u003e3\u003c\/sup\u003e Among these genes are glutathione peroxidase,  superoxide dismutase and various phase II enzymes,  such as glutathione sulfotransferases.\u003csup\u003e4\u003c\/sup\u003e Nrf2 also supports expression of glutathione glutamylcysteinyl ligase,  which is responsible for a critical step in the biosynthesis of glutathione,  a vital component of cellular antioxidant and detoxification systems.\u003csup\u003e5\u003c\/sup\u003e Found in virtually every cell of the body glutathione plays essential roles in protein synthesis,  synthesis and repair of DNA,  enzyme function,  transport and cell maturation.\u003csup\u003e6\u003c\/sup\u003e Optimal levels of glutathione have been associated with physical and mental health.\u003csup\u003e7\u003c\/sup\u003e The highest concentration of glutathione is found in the liver,  where it offers antioxidant support,  protects tissue and maintains detoxification.\u003csup\u003e8, 9\u003c\/sup\u003e In a randomized clinical trial,  supplementation with 250 and 1, 000 mg of Setria\u003csup\u003e®\u003c\/sup\u003e glutathione per day increased glutathione levels in the blood after one,  three and six months. At six months,  mean glutathione levels in the high-dose group increased 30-35% in erythrocytes,  plasma and lymphocytes,  and 260% in buccal cells (p\u0026lt;0.05). In the low-dose group,  mean glutathione levels increased 17% and 29% in blood and erythrocytes,  respectively (p\u0026lt;0.05). Both glutathione dose groups showed support for antioxidant defenses,  indicated by decreases in the oxidized-to-reduced-glutathione ratio in whole blood after six months.\u003csup\u003e10‡\u003c\/sup\u003e\n\u003c\/div\u003e\u003cdiv class=\"accordion-attribute accordion-attribute-references\"\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eZhang Y,  et al. \u003cem\u003eProc Natl Acad Sci U S A.\u003c\/em\u003e1992 Mar 15;89(6):2399-403. \u003c\/li\u003e\n\u003cli\u003eKaren-Ng LP,  et al. \u003cem\u003eAsian Pac J Cancer Prev.\u003c\/em\u003e 2011;12(5):1161-6.\u003c\/li\u003e\n\u003cli\u003eKrajka-Kuzniak V,  et al. \u003cem\u003eJ Physiol Biochem.\u003c\/em\u003e2015 Jun;71(2):227-38.\u003c\/li\u003e\n\u003cli\u003eBrooks JD,  et al. \u003cem\u003eCancer Epidemiol Biomarkers Prev.\u003c\/em\u003e2001 Sep;10(9):949-54.\u003c\/li\u003e\n\u003cli\u003eKode A,  et al. \u003cem\u003eAm J Physiol Lung Cell Mol Physiol.\u003c\/em\u003e2008 Mar;294(3):L478-88.\u003c\/li\u003e\n\u003cli\u003eWu G,  Fang YZ,  Yang S,  etal.\u003cem\u003e J Nutr.\u003c\/em\u003e 2004 Mar;134(3):489-92.\u003c\/li\u003e\n\u003cli\u003eLang CA,  et al.\u003cem\u003e J Lab Clin Med.\u003c\/em\u003e 2002 Dec;140(6):413-7.\u003c\/li\u003e\n\u003cli\u003eHazelton GA,  et al. \u003cem\u003eBiochem J.\u003c\/em\u003e1980 Apr 15;188(1):25-30.\u003c\/li\u003e\n\u003cli\u003eHollins DL,  et al. \u003cem\u003eFree Radic Biol Med.\u003c\/em\u003e 2006 Apr 1;40(7):1220-6.\u003c\/li\u003e\n\u003cli\u003eRichie JP Jr,  et al. \u003cem\u003eEur J Nutr.\u003c\/em\u003e 2015 Mar;54(2):251-63.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/div\u003e\u003ch5\u003e\u003cspan\u003eSpecifications\u003c\/span\u003e\u003c\/h5\u003e\u003cul\u003e\n\u003cli\u003eUPC: Not Specified\u003c\/li\u003e\n\u003cli\u003eGTIN\/ITF Barcode: Not Specified\u003c\/li\u003e\n\u003cli\u003eUnits of Measure: Not Specified\u003c\/li\u003e\n\u003cli\u003eOverall Product Length: Not Specified in\u003c\/li\u003e\n\u003cli\u003eOverall Product Width: Not Specified in\u003c\/li\u003e\n\u003cli\u003eOverall Product Height: Not Specified in\u003c\/li\u003e\n\u003cli\u003eWeight Capacity: Not Specified lbs\u003c\/li\u003e\n\u003cli\u003eActual Product Weight: 0.25\u003c\/li\u003e\n\u003cli\u003eProduct Assembly: Not Specified\u003c\/li\u003e\n\u003cli\u003eProduct Installation: Not Specified\u003c\/li\u003e\n\u003cli\u003eCountry of Origin: Not Specified\u003c\/li\u003e\n\u003cli\u003eCase QTY: Not Specified\/case\u003c\/li\u003e\n\u003cli\u003eCase Weight: Not Specified\u003c\/li\u003e\n\u003cli\u003eShips Via Freight: Not Specified\u003c\/li\u003e\n\u003cli\u003eProposition 65 Warning: Not Specified\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Save On LLC","offers":[{"title":"Default Title","offer_id":48265601941696,"sku":"NRF6","price":64.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1403\/8729\/files\/1778087511220.avif?v=1778087521","url":"https:\/\/tensnet.com\/products\/nrf2-detox","provider":"TENSnet","version":"1.0","type":"link"}