{"product_id":"dao-enzyme","title":"DAO Enzyme","description":"\u003ch5\u003e\u003cspan\u003eDescription\u003c\/span\u003e\u003c\/h5\u003e\u003cdiv class=\"accordion-attribute accordion-attribute-benefits-features\"\u003e\n\u003cul\u003e\n\u003cli\u003ePromotes breakdown of dietary histamine\u003csup\u003e‡\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eReduces gastrointestinal discomfort (occasional diarrhea,  bloating and gas) associated with sensitivity to histamine-rich foods\u003csup\u003e‡\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eEat with greater confidence when histamine may be present in food\u003csup\u003e‡\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eAcid-resistant capsules protect DAO from degradation in the stomach\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\u003cdiv class=\"accordion-attribute-container\"\u003e\n\u003cdiv class=\"accordion-attribute accordion-attribute-indications\"\u003e\n\u003ch2\u003eIndications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAges 18 and up\u003c\/li\u003e\n\u003cli\u003eIndividuals who experience symptoms of histamine intolerance,  such as occasional GI upset,  skin sensitivity or flushing\u003csup\u003e‡\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"accordion-attribute accordion-attribute-suggested_use\"\u003e\n\u003ch2\u003eSuggested Use\u003c\/h2\u003e\n\u003cp\u003eAs a dietary supplement,  take 1 capsule,  2-3 times daily,  with each meal,  or as directed by a health care professional.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e \u003cdiv class=\"accordion-attribute accordion-attribute-verifiable_science\"\u003e\n\u003ch2\u003eVerifiable Science\u003c\/h2\u003eHistamine is a substance found in many foods,  such as meats,  spinach,  fermented foods,  avocadoes,  nuts,  tomatoes and chocolate. An estimated 1-3% of the population cannot digest dietary histamine efficiently,  often because of low intestinal diamine oxidase (DAO),  an enzyme in the GI tract that normally breaks down histamine. These individuals often experience gastrointestinal discomfort,  headache,  skin sensitivity or flushing after consuming histamine-containing foods.\u003csup\u003e1\u003c\/sup\u003e Supplementation with DAO enhances DAO activity in the GI tract,  promoting breakdown of dietary histamine and reducing gastrointestinal discomfort (occasional diarrhea,  bloating and gas) associated with sensitivity to histamine-rich foods.\u003csup\u003e3\u003c\/sup\u003e DAO may also reduce skin symptoms associated with high intestinal histamine levels.\u003csup\u003e6\u003c\/sup\u003e In an open-label pilot study,  individuals with low DAO levels (\u0026lt; 10 U\/ml) who received DAO (10, 000 HDU) up to 3 times per day reported significant improvements in gastrointestinal,  respiratory and skin symptom scores after 4 weeks. Subjects reported significant improvement in gastrointestinal comfort,  including occasional diarrhea,  bloating and gas,  headache,  respiratory and skin discomfort.\u003csup\u003e3\u003c\/sup\u003e In a double-blind,  placebo-controlled,  crossover investigation of 22 patients,  supplementation of 10, 000 HDU DAO twice daily for 30 days improved dietary histamine-associated skin discomfort.\u003csup\u003e6 ‡\u003c\/sup\u003e\n\u003c\/div\u003e\u003cdiv class=\"accordion-attribute accordion-attribute-references\"\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eComas-Basté O,  Sánchez-Pérez S,  Veciana-Nogués MT,  et al. Biomolecules. 2020 Aug 14;10(8):1181.\u003c\/li\u003e\n\u003cli\u003eSánchez-Pérez S,  Comas-Basté O,  Costa-Catala J,  et al. Front Nutr. 2022 May 25;9:897028.\u003c\/li\u003e\n\u003cli\u003eSchnedl WJ,  Schenk M,  Lackner S,  et al. Food Sci Biotechnol. 2019; 28(6): 1779-1784.\u003c\/li\u003e\n\u003cli\u003eManzotti G.,  Breda D.,  Di Gioacchino M.,  Burastero S.E. Int J Immunopathol Pharmacol. 2016;29:105–111.\u003c\/li\u003e\n\u003cli\u003eKomericki P.,  Klein G.,  Reider N.,  et al. Wien Klin Wochenschr. 2011;123:15–20.\u003c\/li\u003e\n\u003cli\u003eYacoub MR,  et al. Int Arch Allergy Immunol. 2018;176(3-4):268-271.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/div\u003e\u003ch5\u003e\u003cspan\u003eSpecifications\u003c\/span\u003e\u003c\/h5\u003e\u003cul\u003e\n\u003cli\u003eUPC: Not Specified\u003c\/li\u003e\n\u003cli\u003eGTIN\/ITF Barcode: Not Specified\u003c\/li\u003e\n\u003cli\u003eUnits of Measure: Not Specified\u003c\/li\u003e\n\u003cli\u003eOverall Product Length: Not Specified in\u003c\/li\u003e\n\u003cli\u003eOverall Product Width: Not Specified in\u003c\/li\u003e\n\u003cli\u003eOverall Product Height: Not Specified in\u003c\/li\u003e\n\u003cli\u003eWeight Capacity: Not Specified lbs\u003c\/li\u003e\n\u003cli\u003eActual Product Weight: 0.25\u003c\/li\u003e\n\u003cli\u003eProduct Assembly: Not Specified\u003c\/li\u003e\n\u003cli\u003eProduct Installation: Not Specified\u003c\/li\u003e\n\u003cli\u003eCountry of Origin: Not Specified\u003c\/li\u003e\n\u003cli\u003eCase QTY: Not Specified\/case\u003c\/li\u003e\n\u003cli\u003eCase Weight: Not Specified\u003c\/li\u003e\n\u003cli\u003eShips Via Freight: Not Specified\u003c\/li\u003e\n\u003cli\u003eProposition 65 Warning: Not Specified\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Save On LLC","offers":[{"title":"Default Title","offer_id":48266226401472,"sku":"DAE6","price":49.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1403\/8729\/files\/1778088639469.avif?v=1778088642","url":"https:\/\/tensnet.com\/products\/dao-enzyme","provider":"TENSnet","version":"1.0","type":"link"}