MSM – methylsulfonylmethane – is the oxidized form of dimethyl sulfoxide (DMSO), an organic-sulfur compound. MSM naturally occurs in some green vegetables and other foods and in the human body, in many animals, and in milk. It’s also found in phytoplankton which live in the oceans.
Many benefits are attributed to MSM due to its biologically active sulfur, which is needed for many different critical bodily functions every single day. Studies have shown that supplementation with MSM can support healthy joints and related connective tissues, support healthy levels of inflammation, support the immune system, and support healthy skin.‡
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
One capsule three times daily.
Count
SKU 840 – 90 Capsules
SKU 8401 – 180 Capsules
Science
Ezaki J, Hashimoto M, Hosokawa Y, Ishimi Y. Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. J Bone Miner Metab. 2013 Jan;31(1):16-25. doi: 10.1007/s00774-012-0378-9. Epub 2012 Aug 10. PMID: 23011466.
Xu G, Zhou T, Gu Y, Wang Q, Shariff M, Gu P, Nguyen T, Shi R, Rao J. Evaluation of the Effect of Mega MSM on Improving Joint Function in Populations Experiencing Joint Degeneration. Int J Biomed Sci. 2015 Jun;11(2):54-60. PMID: 26199577; PMCID: PMC4502733.
Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651. doi: 10.1101/cshperspect.a001651. Epub 2009 Oct 7. PMID: 20457564; PMCID: PMC2882124.
Ahn H, Kim J, Lee MJ, Kim YJ, Cho YW, Lee GS. Methylsulfonylmethane inhibits NLRP3 inflammasome activation. Cytokine. 2015 Feb;71(2):223-31. doi: 10.1016/j.cyto.2014.11.001. Epub 2014 Nov 21. PMID: 25461402.
Amirshahrokhi K, Khalili AR. Methylsulfonylmethane is effective against gastric mucosal injury. Eur J Pharmacol. 2017 Sep 15;811:240-248. doi: 10.1016/j.ejphar.2017.06.034. Epub 2017 Jun 28. PMID: 28666801.
van der Merwe M, Bloomer RJ. The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. J Sports Med (Hindawi Publ Corp). 2016;2016:7498359. doi: 10.1155/2016/7498359. Epub 2016 Oct 23. PMID: 27844051; PMCID: PMC5097813.
Barmaki S, Bohlooli S, Khoshkhahesh F, Nakhostin-Roohi B. Effect of methylsulfonylmethane supplementation on exercise – Induced muscle damage and total antioxidant capacity. J Sports Med Phys Fitness. 2012 Apr;52(2):170-4. PMID: 22525653.
Withee ED, Tippens KM, Dehen R, Tibbitts D, Hanes D, Zwickey H. Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2017 Jul 21;14:24. doi: 10.1186/s12970-017-0181-z. PMID: 28736511; PMCID: PMC5521097.
Nimni ME, Han B, Cordoba F. Are we getting enough sulfur in our diet? Nutr Metab (Lond). 2007 Nov 6;4:24. doi: 10.1186/1743-7075-4-24. PMID: 17986345; PMCID: PMC2198910.
Schagen SK, Zampeli VA, Makrantonaki E, Zouboulis CC. Discovering the link between nutrition and skin aging. Dermatoendocrinol. 2012 Jul 1;4(3):298-307. doi: 10.4161/derm.22876. PMID: 23467449; PMCID: PMC3583891.
Features :
Hygienic Product : Not Specified
Allergy : Not Specified
Description
MSM – methylsulfonylmethane – is the oxidized form of dimethyl sulfoxide (DMSO), an organic-sulfur compound. MSM naturally occurs in some green vegetables and other foods and in the human body, in many animals, and in milk. It’s also found in phytoplankton which live in the oceans.
Many benefits are attributed to MSM due to its biologically active sulfur, which is needed for many different critical bodily functions every single day. Studies have shown that supplementation with MSM can support healthy joints and related connective tissues, support healthy levels of inflammation, support the immune system, and support healthy skin.‡
Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.
‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
Ingredients
Dosage
One capsule three times daily.
Count
SKU 840 – 90 Capsules
SKU 8401 – 180 Capsules
Science
Ezaki J, Hashimoto M, Hosokawa Y, Ishimi Y. Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. J Bone Miner Metab. 2013 Jan;31(1):16-25. doi: 10.1007/s00774-012-0378-9. Epub 2012 Aug 10. PMID: 23011466.
Xu G, Zhou T, Gu Y, Wang Q, Shariff M, Gu P, Nguyen T, Shi R, Rao J. Evaluation of the Effect of Mega MSM on Improving Joint Function in Populations Experiencing Joint Degeneration. Int J Biomed Sci. 2015 Jun;11(2):54-60. PMID: 26199577; PMCID: PMC4502733.
Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651. doi: 10.1101/cshperspect.a001651. Epub 2009 Oct 7. PMID: 20457564; PMCID: PMC2882124.
Ahn H, Kim J, Lee MJ, Kim YJ, Cho YW, Lee GS. Methylsulfonylmethane inhibits NLRP3 inflammasome activation. Cytokine. 2015 Feb;71(2):223-31. doi: 10.1016/j.cyto.2014.11.001. Epub 2014 Nov 21. PMID: 25461402.
Amirshahrokhi K, Khalili AR. Methylsulfonylmethane is effective against gastric mucosal injury. Eur J Pharmacol. 2017 Sep 15;811:240-248. doi: 10.1016/j.ejphar.2017.06.034. Epub 2017 Jun 28. PMID: 28666801.
van der Merwe M, Bloomer RJ. The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. J Sports Med (Hindawi Publ Corp). 2016;2016:7498359. doi: 10.1155/2016/7498359. Epub 2016 Oct 23. PMID: 27844051; PMCID: PMC5097813.
Barmaki S, Bohlooli S, Khoshkhahesh F, Nakhostin-Roohi B. Effect of methylsulfonylmethane supplementation on exercise – Induced muscle damage and total antioxidant capacity. J Sports Med Phys Fitness. 2012 Apr;52(2):170-4. PMID: 22525653.
Withee ED, Tippens KM, Dehen R, Tibbitts D, Hanes D, Zwickey H. Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2017 Jul 21;14:24. doi: 10.1186/s12970-017-0181-z. PMID: 28736511; PMCID: PMC5521097.
Nimni ME, Han B, Cordoba F. Are we getting enough sulfur in our diet? Nutr Metab (Lond). 2007 Nov 6;4:24. doi: 10.1186/1743-7075-4-24. PMID: 17986345; PMCID: PMC2198910.
Schagen SK, Zampeli VA, Makrantonaki E, Zouboulis CC. Discovering the link between nutrition and skin aging. Dermatoendocrinol. 2012 Jul 1;4(3):298-307. doi: 10.4161/derm.22876. PMID: 23467449; PMCID: PMC3583891.
